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    If something is repeated enough, it often becomes fact. It doesn't matter if it is true or not; it only matters that it is accepted as fact by a majority of people. If unt
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    rue, it will remain fact until it is proven to be untrue.

    A good example of this is the common belief that animals have a sixth sense. There is no scientific or other evid
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ence to prove this theory, and yet it is a "fact" to a majority of people. Moreover, those who hold to this view, have, over time, evolved this claim to include more abilit
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    y than even the term suggests. Animals not only have a heightened sense of awareness, but they also have the ability to perceive supernatural phenomenon and natural disaste
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    rs as well.

    Without doubt animals seem to "know" about certain things before people are aware of them. An earthquake is a good example. It has been documented that dogs,
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    cat, birds, horses and a host of other animals react to an earthquake many seconds before the quake is felt by humans.

    A television documentary on the extraordinary senses
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    of animals included the recording of a test conducted on how birds reacted to an explosion. A building was being demolished and just before the explosion occurred, the scor
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    es of pigeons perched on the outside ledges of the building lifted off and flew to safety before the physical impact on the building was seen.

    Cameras had been set up in st
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    rategic locations to capture the behavior of the birds. The footage was amazing. From the video it was clear that the pigeons' sixth sense had kicked in and warned them of
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    impending danger and they responded to it before it occurred. Or had they?

    Closer examination of the footage run at a very slow speed revealed that at the time of detona
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    tion, the pigeons had not moved. The explosion occurred first and then, nearly a full second later, the pigeons reacted to the percussion and lifted off the ledge just befo
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    re the effects of the explosion reached them.

    Mounting evidence invariably supports that it is indeed the heightened senses of animals that allow them to "feel" things befo
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    re people. In the case of an earthquake, for example, animals can feel rumblings deep inside the earth well before they are ever felt by people.

    When it comes to the super
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    natural, there is a wealth of folk lore fables, but no qualitative evidence to suggest they have any supernatural sense. Indeed, it seems this is one area where mankind has
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    an advantage over the animals; for without doubt people have a sixth sense.

    On every continent, in every culture, in every time, people "feel" there is a God. Behind the
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    iron and bamboo curtains, on the plains of Mongolia, behind the bushes of the Amazon jungle, people everywhere have a "sense" of God.

    I like to refer to this sense as SONG,
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    a simple acronym for the Sense of Our Need for God. Inside each human being there exists an awareness of God. This sense transcends culture, race, gender and age. Childr
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    en of every nation have an awareness of God. Everyone as a child shared this belief. You may not remember it. Time and life's experiences may have robbed you of the memor
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    y of it. But you once had an awareness of God. We are all born with it.

    Man is unique among all God's creatures. We are made in his image. We know he is there. We know
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    we can talk to him. We have a "sense" that tells us this, a sixth sense. It is we who have this special sense and not the animals. Have you taken advantage of that sense


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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