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19th Century: In 1836, General Santa Ana and 3,000 Mexican troops laid siege to the Alamo in the Texas Revolution. Santa Ana wiped out the entire garrison of approximately 187 men

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

. Because of this massacre, a hewn cry went up throughout the southwest, "Remember the Alamo."

20th Century: On December 7, 1941, Japanese naval and air force m

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

de a sneak attack on Pearl Harbor in Hawaii. As countless bombs and torpedoes dropped from the air, the battleship Arizona capsized trapping and subsequently entombing over a thou

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

sand navy men. President Roosevelt went on the radio and relayed the news around the world that the Japanese had attacked Pearl Harbor and that that day would live in infamy. Thus

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

another cry in another century went out over the United States and the western world, "Remember Pearl Harbor."

21st Century: September 11, 2001, al-Qaeda terror

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ists hijacked United and American Airlines and crashed them into the world Trade Center and Pentagon attack America. When the dust cleared in the aftermath of this Islamic suicid

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

horror, nearly three thousand innocent civilians and public heroes had lost their lives. The silent but urgent heart cries heard around our great country, "Remember 9/11.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

"

As the thief was dying on the cross next to Jesus, he makes the plea, “Lord, when you come into your kingdom, Remember Me."

But Paul, writing to Timo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

hy, says, "Remember Jesus Christ, raised from the dead, descended from David. This is my gospel,…”

Whenever we face a crisis or we encounter a bend in the road o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

f life, "Remember Jesus Christ." In other words, bring Him into view. This is always God’s remedy at any time and in any situation. Throughout the writings of the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Apostle Paul, we read of his resorting to this method of dealing with the difficulties he was experiencing. For example at Philippi, where there was considerable disagreements and

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

lack of unity, Paul said: “Let this mind be in you, which was also in Christ Jesus.” The greatest corrective action is to remember Jesus Christ.

As Christians, we have been bles

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ed with another life through Jesus Christ, a life incorruptible and we must live on the basis of that life. We must remember that it is not necessary for us to become psychologica

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lly disjointed or mentally disturbed by what goes on around us. We have in us a life, the very all-sufficient life of God, which in Christ Jesus has overcome the world and corrupt

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

on.

"Remember Jesus Christ." Remember that in Him, there is that Person which went through all corruption untainted, and it is also possible for

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

us to walk as saints in the midst of Sodom and Gomorrah.

Paul is reminding us to remember Jesus Christ. He wanted us to know that somehow in the midst of life’s brokenness--in a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

society that breeds corruption, in a system where children are being molested and murdered, where man’s inhumanity has reached a devastating plateau, where threats to our livelih

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ood is a daily concern and nuclear holocaust hangs heavy over our heads, we have got to "Remember Jesus Christ."

It is the wondrous miracle of the Christian’s li

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e that we may be exposed to all the horror and degradation, all the sin and pollution of this world and still walk our path untainted and unstained. It is not our life and it is n

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ot the way of our Lord. The life we have in Jesus Christ is not one imposed upon us by the world. Rather, we “are kept” by the power of God in Jesus Christ.

Remember Jesus Christ

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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