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Between 7 and Midnight.

The Midnight hour is a transition between, one day, and another. It is the end of one thing, and the beginning of something new. At midnight, we see the death of the past, and the birth of the future.

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

We see a day that cannot be changed, and a day, that is still open for choices. In the past we see the hours of prophecy being fulfilled. What we did yesterday, will hang on to us, until the future is no more, unless we make the right choices.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

We will all have to live with the choices of the past, which will give way to the life we still must live. Some of th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ese choices at midnight will haunt us, and others will endow us with joy.

Our time peaces have hours, and minutes, why then wouldn't our days upon this earth, speaking of a beginning and an end. Do you believe that you will live forever, or believe that after death, the spirit, that you lived with, will not en

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ure? Can you say that, all you were, all you accomplished, and all that you did, will not be brought before a High Judge, for accountability? Even the unbelievers curse those, that have caused great harm in their lives, they call upon Hell to receive them. If they truly do not

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

believe in God, or an after life, why then would they call for punishment of them, if there is truly no life after death? This is because they are lying to themselves. Every man believes in God and judgment, weather they be an atheist or an agnostic.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Time is both a friend and an enemy, we will all run out our time on earth, and begin a new life without time.

Job 34:20 In a moment shall they die, and the people shall be troubled at midnight, and pass away: and the mighty shall be taken away without hand. In the past we have seen th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e seventh hour. A time of great darkness, both spiritually and physically. This was a time when few men, could read the word of truth. Education was only for the rich and powerful. Multitudes were kept in darkness and ignorance, but still each person would

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

be judged on their lives, weather they served well, or poorly. This darkness was brought on threw mans quest, for absolute power over his fellow man. With darkness comes ignorance and servitude.

Shall there be vengeance at midnight, will there be judgment, and punishment at this new hour? And shall not God avenge hi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s own elect, which cry day and night unto him, though he bear long with them? (Luke 18:7) We have seen from the seventh hour until now, how the elect of God are persecuted, harassed and made sport of, by those that are ignorant of the truth. Will this all stop? At the midnight hour it will. God made

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

time for man, and not for Himself, for He is, from everlasting to everlasting. God has used His creation of time, to announce a destiny, for this earth and man himself, from the first hour, the time of creation, to the midnight, or last hour, the retur

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

n of Christ to judge all of their ungodly works. To execute judgment upon all, and to convince all that are ungodly among them of all their ungodly deeds which they have ungodly committed, and of all their hard speeches which ungodly sinners have spoken against him. (Jude 1:15)

The time of judgment is coming in this m

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

dnight hour, weather you be saint or sinner. And at midnight there was a cry made, Behold, the bridegroom cometh; go ye out to meet him. (Matthew 25:6) At midnight I will rise to give thanks unto thee because of thy righteous judgments. (Psa 119:62 ) The judgments, that God will hand out, will be two different things

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

. The judgment of the just, and the condemnation of the unjust. And many of them that sleep in the dust of the earth shall awake, some to everlasting life, and some to shame and everlasting contempt. (Dan 12:2) And they shall go forth, and look upon the carcases of the men that have transgressed against me: for thei

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r worm shall not die, neither shall their fire be quenched; and they shall be an abhorring unto all flesh. (Isa 66:24) Do men transgress against man, or God? Do men sin against man, or God? Do men pass, over or beyond, the limits tha

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t God has laid down? Is this transgression a sign of the midnight hour? Most assuredly. For we see the signs of the times, in the sky, the sea, the earth and also in the heavens. This transgression and sin is not against man, but rather against God, for it is written that, all men have sinned, but we shall be judged o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

our works, weather they be good or evil.

And whereas thou sawest iron mixed with miry clay, they shall mingle themselves with the seed of men: but they shall not cleave one to another, even as iron is not mixed with clay. And in the days of these kings shall the God of heaven set up a kingdom, which shall never be d

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

estroyed: and the kingdom shall not be left to other people, but it shall break in pieces and consume all these kingdoms, and it shall stand for ever. (Dan 2:43-44) The hard speeches, which ungodly sinners have spoken against God, will come back to haunt them. The mockers, of these end days, shall give account of every

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

idle word, and shall be judged by an everlasting judgment. Why do they speak against God that they say doesn't exist, cant they leave Our Lord alone, after all He endured for them?

Rev 14:18 And another angel came out from the altar, which had power over fire; and cried with a loud cry to him that had the sharp sickl

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e, saying, Thrust in thy sharp sickle, and gather the clusters of the vine of the earth; for her grapes are fully ripe. Remember what you have read, and make your choice carefully; “The Midnight hour is a transition between, one day, and another. It is the end of one thing, and the beginning of something new.” ars

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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