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Surf the 'Net for about 10 minutes and chances rate very high that you'll encounter an error of one kind or another.

Whether the error message pops up on your own

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

computer or on a website loaded in your browser, knowing what the error means can help you solve the problem much faster and avoid hours of frustration (especial

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ly in a situation where nothing you do will solve the problem).

The following represent some of the more common error messages you may encounter while surfing the

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Internet and what (if anything) you can do to correct the situation.

Error: 404 File Not Found

This means the web server cannot find the file or web page you tr

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ed to pull up in your web browser.

Almost nothing you can do will correct this situation. Try hitting your web browser's "Refresh" button to see if the page will

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

load. If not, email the website operator to let them know of the problem and then move on.

Error: 500 Internal Error

This error usually occurs when you fill in a

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

form on a web page (contact form, shopping cart, feedback form) and click the submit button.

This means the server or the script handling the form on the server

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

has a major problem. Again, there's nothing you can do so just email the website owner and move on.

By the way, resubmitting the form a dozen times, banging your

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

and on the keyboard, and yelling at your monitor won't fix the problem!

Error: 408 Request Timeout

This error usually occurs when you try to download a huge file

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

or large web page and, for whatever reason, the connection times out.

Simply hit your browser's "Refresh" button and it should pick up the download again where y

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ou left off.

If not, contact the website owner and inform them of the problem or check back later.

Error: Host Unavailable

Grab a cup of coffee on this one and f

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

all back to reading the newspaper.

You can try hitting your "Refresh" button a couple of times, but, for all intents and purposes, this means the server has gone

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

down.

Try again in a few minutes on the off-chance you tried to access the website just as the owners were restarting the server or temporarily disconnected it fr

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

om the Web.

If this doesn't work, the phone rates your best course of action to contact the website owner since it's a safe bet their email won't work either.

Er

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ror: Unable to Locate Host

This message usually means one of three things: the web server is down; your Internet connection is dead; you typed in the web address

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

incorrectly.

To correct the problem, first try retyping the web address into your browser's address bar. If that doesn't work, try surfing over to another website

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

to make sure your connection is live.

If you can't load any websites, contact your Internet service provider (ISP) for technical assistance.

As a general rule, i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

f you encounter an error while surfing the web, try these steps in order to fix the problem:

1. Click your Web browser's "Refresh" button.

2. Verify that you typ

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ed in the correct URL (web address)

3. Close down and restart your Web browser completely.

4. Contact the website owner to alert them to the problem or request he

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

One of the smartest things a business leader can do in their company is post monthly communication letters to employees. Of course now with all the over regulation out there the lawyers will have to look at it to make sure what you are saying is not breaking any laws, but it is a great way to build team work and increase dedication with the employees.

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