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iPod nano is infamous for being prone to scratches. The surface is so easily scratched that people had been scratching it within the hour of opening the box. This may be because Apple used a different formula of polycarbonate than previous iPod

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

models. Regardless of why it is the case, scratches suck; especially so when it is on the nano. The nano being so small the scratches especially noticeable and damaging to the experience since they take up larger portions of space. Even a sin

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

gle scratch on the screen could ruin everything.

Like many people, I didn't buy the rumors. I treat my stuff with great care; I was going to be an exception to the scratches. It sucks to be wrong. Now, it is many moons after the fact. Compar

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ed to the early days we now have a lot more accessories and products to help us keep our nano minty fresh, if we are willing to pay for them. There are also products aimed to bring back the polish of those unfortunate, disfigured nanos. Hopeful

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ly, you aren't on the same path as I was on.

Early Preventions:

The best course of action of course is to prevent your nano from being scratched in the first place. Unlike the very early days of nano, there are now an abundance of cases and sk

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ins you can protect your precious with; get one when you buy a nano. Stories of scratching the iPod nano with an hour of opening the box are actually true; sad as it is the nano scratches that easily. Nowadays, Apple ships the nano with a slip

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

case, so perhaps it won't wear as quickly. That slip case however, is not the most effective of methods or the most pretty. Trust me on this, shelling some extra cash out for a nice case is well worth it if you want to keep it smooth and pretty

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

.

One of the best skin cases out there for nano is iSkin Duo. They feature an ingenious two layer design that protects the nano with near perfection. Everything except the hold switch is covered, and covered well. Beyond the awesome protectio

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

n it provides, they also come in a variety of color combinations (the outer layer and inner layer have different colors); not only do they work, they look good doing in. You should definitely consider checking them out. The list price may seem

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a bit high, but you can usually find them selling for much lower than that online. And even at list price, this skin is well worth the money.

But what if you are looking for more? You want a case with even better protection: one that withstand

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s scratches, dust, shock and even water. Well, in that case you are in luck. OtterBox makes such a case for nano; a scratch/dust/shock/water proof, thick plastic case. This is what I call overkill protection; it isn't a case, it is a thick lay

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

er of armor. This think is simply beyond the line of duty for most people. The only down side is that it is quite bulky.

For those who do not wish to alter the look of their iPod, you can get some adhesive protective film covers for some skin

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

tight protection. Just stick them onto your nano and you have yourself a form fitting layer of scratch protection. They aren't going to provide much protection beyond scratching, though. Power Support films had been quite popular, so you may w

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ish to check them out if this type of protection is what you are looking for. Keep in mind that a lot of film sets cover only the front and back surfaces but not the sides, so be sure to check before you buy. Also, some films do not adhere well

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

(quite useless if that is the case) so be sure to check some reviews first before purchasing.

Late Stages:

So your iPod is terminally disfigured. Its beautiful surface scratched up; worse yet some scratches are on the display and now an "n" l

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ooks like an "m" and you can no longer tell between “c” and “o”. All is not lost. There are still ways to reduce the damage, even though you may not be able to reverse it. There are various brands of scratch removal polish that can help. The

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

thing to know is that they are not perfect; although they do make a difference. They can reduce the severity of scratches but they cannot completely remove them.

There are a few notable iPod scratch removers, such as iDrops, iCleaner, Radtech I

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ce Creme and various ones from the company Radtech. Some work better than others of course, so be sure to check for reviews. A thing to note when using these products, regardless of the brand, is to follow the instructions. A lot of people app

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ly them intuitively, but doing so may not get you the full effect; taking a few minutes to read through the instructions is well worth it for a better result.

If you are one of the few who don’t mind scratches, I envy you whole heartedly. But f

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

or those who do care, there are many measures you can take to avoid scratches or to reduce them; prevention is always the best option though. Hopefully they next generation won’t be so scratch prone, but for now, we’ll just have to deal with it.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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