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    The problem of fire fighting is one of the most actual problems of our time because despite the great technological progress made by mankind the fire still causes a lot of disasters and catastrophes. Since ancient times the situation has hardly changed for as soon as fire appeared in human’s life it brought not only warm and better opportunities to survive but also it brought a great danger that people very often couldn’t cope with. Logically, the most progressive part of mankind tried to do their best to solve and, certainly, to prevent this problem. As human race evolved the technology evolved too. The most up-to-date machines and technologies have replaced old means of fire protection. And in the future man is supposed to be completely rep
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    laced by special machines and devices that will have remote control and won’t need man’s presence. So, it is evident that scientists and researchers tend to make fire fighting less dangerous and more controllable.

    But, unfortunately, sometimes enormous territories may be in fire and at first it seems impossible to stop it. Exactly for such cases aircraft fire fighting vehicles are used. Also it is necessary to underline that with the development of airplane and space industry appeared the danger of fire on the board of planes and space vehicles or even stations. So there is a large sphere where aircraft fire protection is needed. This branch of fire fighting doesn’t have a very long history in comparison with others and we can say that it is
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    the most modern and highly technological industry which deals with fire fighting.

    Actually, we can estimate that aircraft rescue fire fighting vehicles appeared as soon as airplane industry appeared. Anyway, at least the idea of such vehicles appeared on the dawn of ‘the space era’ because as usual any new thing causes new problems so airplanes made people think about safety of flights and the possible usage of new kind of vehicles for the people’s sake. As for the history of aircraft rescue fire fighting vehicles their necessity became quite obvious at the period of World War II when the problem of air crashes and aircraft fire fighting increased to the great dimension because appeared such problems as the problem of the flights’ safety, a
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    well as the problem of airports’ safety and some other correlating problems.

    Thus, when we speak about aircraft rescue fire fighting we must take into account two dimensions: airports’ fire security and aircraft rescue fire fighting vehicles themselves. A great experience in this sphere have the USA because at this period of time the rescue services were not developed well enough to provide the necessary help to people who were crashed and needed emergent aid. As a result a lot of people died though on the condition that fire fighting services had all essential equipment. Unfortunately, this extremely negative experience was practically forgotten after the war and existing systems were not effective enough to prevent serious fire accidents.
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    The analysis made by the Airline Pilot Association in 1968 discovered that the majority of American commercial airports were not appropriately equipped and the only way out to avoid an enormous damage in the case of fire was the appeal to local municipal fire fighting services. Such situation couldn’t remain unchanged.

    That is why since 1947 they had begun to develop airline commercial industry and at this moment it became obvious that the war experience may be used in civil aircraft rescue fire fighting and they had begun to implement the equipment of the war period. But due to the fact that some equipment and technologies were secret it was very difficult to rediscover those technologies that were used only for military purposes. At that
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    time, airports, both commercial and military, traditionally used protein foam and bulk carbon dioxide as combined primary agents. The characteristics of agent were borrowed from the war experience and were technically limited because of the lack of ARFF vehicles of necessary type that were at the disposal of airports. The formula was calculated from the average amount of agent that was known from the experience of past accidents and the size of aircraft and maximum gross take off weight was the most important things for categorization here. The quantity of agent that was needed depended on the size of the largest aircraft that could land at the airport.

    It seems strange enough but despite the fact that the formula was known in early post war
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    years but it was kept in secret and couldn’t be published. It was finally promulgated only in 1951 and had only a status of suggestions. Only in the 1970-es it was officially recommended to use in everyday fire fighting practice and only in 1988 it had got the status of the standard. Later on the International Civil Aviation Organization worked out a number of suggestions for aircraft rescue fire fighting requirements. Periodically these requirements had been modernized and improved. Also there were created special work groups that had to control and to focus the development of technologies on the more scientific basis. These working groups could test the equipment and suggest their improvements that would be necessary to make.

    Eventually, t
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    here appeared a formula for determining agent quantities and it became an international standard that exists even nowadays. The principle idea of this formula is based on the fact that fuselage integrity must be kept unchangeable to provide the survival of passengers or crew members. The tests demonstrated that it could be done only by keeping fire at least 50 feet away from fuselage and that people could have less than a minute to save themselves and to cope with the fire. These standard data were projected to different types of aircraft of different size. It is quite natural that one need a very good knowledge of the subject and a great experience to make such calculations as well as one must test it in order not to make a mistake. That is
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    hy specialists decided to classify all aircraft to avoid this problem that any airport could have. Thus, all aircraft were grouped into eight categories and since that time and now on the length of fuselage has become the principle factor that has replaced gross weight.

    Nowadays one of the main problems that scientists and engineers try to resolve is the problem of the safety of fire fighters, the safety of our environment and nature and, finally, the last but not the least problem is the problem of water waste. Engineers work on different apparatus that could correspond to all characteristic mentioned above. Among the latest machines we can name Aqueous Film Forming Foam (AFFF) extinguishing systems, a No Foam Kit and others. As for AFFF e
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    tinguishing systems we can say that current design standards include both overhead and low level AFFF extinguishing systems. The overhead AFFF system typically consists of standard closed head sprinklers that are zoned within areas defined by draft curtains. In some existing installations, the overhead systems are open head deluge systems the low level system typically consists of multiple high flow monitors. The low level AFFF and overhead deluge sprinkle systems are activated by separate detection systems.

    Due to high cost incurred from damage of aircraft and electronics resulting from accidental discharges of the overhead AFFF system, researchers are exploring alternate suppression techniques. They propose the approach that would replace
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    he overhead foam suppression system with a closed-head water sprinkler system and it would permit to minimize the time delay in activating the overhead system through the use of quick response sprinklers. At the same time test showed that a low level AFFF system alone could achieve rapid fire control and extinguishment without the use of overhead sprinklers.

    But nowadays scientists are working on safer and better systems that could replace those which were mentioned above. One of such innovative and very prospective system is No Foam Kit. A No Foam Kit has been developed and demonstrated in order to replace Aqueous Film Forming Foam (AFFF) with a benign, biodegradable dye or water mixture that eliminates the need to release AFFF for operatio
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    al maintenance and routine checks. The use of the kit produces a waste stream that can be assimilated by nature and can be recycled easily at recycling plants, thus producing a complete reduction of the problematic AFFF wastewater stream.

    For the Aircraft Rescue Fire Fighting (ARFF) vehicle is currently a main line of defence at shore-base airfields facilities these vehicles must be periodically tested, used for training, and maintained to provide for appropriate operational readiness. The vehicles use an AFFF for fire suppression. Despite its wide use and effectiveness for fire fighting, AFFF poses an environmental risk because of its resistance to biodegradation, its toxicity, and its high Biological Oxygen Demand and Chemical Oxygen Dema
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    d. In addition, AFFF has been prohibited for discharge to the ground and treatment plants at many facilities due to its non-biodegradable nature, its extreme foaming capacity, and its tendency to upset biological treatment systems. The combination of these issues has created a conflict of needs with regard to meeting operational requirements in the protection of life and property and the stewardship of the environment.

    The No Foam Kit has been demonstrated as an alternative system to the existing ARFF vehicles models CF4000L (Amertek) and P-19 (Oshkosh). In the cab of the vehicle, the fire fighter simply pushes and holds a push-button to activate the kit. Then the fire fighter continues through the normal fire fighting discharge procedure. A
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    flow sensor installed in the kit piping sends electrical signals to the meter in the cab. The fire fighter simply reads and quickly determines the vehicle’s AFFF delivery system performance. By releasing the push-button the kit is deactivated and the vehicle is in the ready, fire fighting mission mode.

    This system is considered to be very prospective because the use of a No Foam Kit can greatly assist facilities in meeting material pre-treatment standards for discharges of wastewater into publicly owned treatment works. In addition, this treatment process may help facilities meet the requirements of waste reduction.

    Under U.S. Naval Fire Protection Program (NAVFAC Guideline P-1021) and National Fire Protection Association (NFPA) requirement
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    s, tests and training on the vehicles and structural pumpers are mandated quarterly and annually. In some cases, based on local airfield requirements, fire chiefs often conduct daily, weekly, or monthly AFFF system tests in addition to the mandated requirements. The use of the No Foam Kit provides an opportunity to meet or exceed these mandates without environmental consequence.

    The compliance benefits listed here are only meant to be used as general guidelines and are not meant to be strictly interpreted. Actual compliance benefits will vary depending on the factors involved, e.g., the amount of workload involved.

    In the process of testing of No Foam Kit no materials compatibility issues were identified. Moreover it was proved to be saf
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    for human’s health because the tests also showed that there were not found any issues dangerous for health or which could be environmentally dangerous. Also this system has a lot of other benefits the most important of which are as follows: it uses biodegradable and environmentally benign dye solution or water to test the onboard foam distribution system; it reduces AFFF wastewater normally generated during fire fighting equipment testing, which reduces: groundwater contamination; wastewater treatment plant upsets, and hazardous waste management and disposal requirements; also it returns quickly to the foam mode after testing-ready for the fire fighters missions; fire chiefs may perform ARFF vehicle discharge tests more frequently while stay
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    ng in environmental compliance; it requires minimal training for fire fighters to operate the kit.; the equipment is highly cost-effective.

    As for disadvantages no one has been found yet though we must remember that all new equipment needs more time for thorough analysis of its advantages and disadvantages and its influence on people and environment.

    But at the same time there is one more very important factor in favour of the No Foam Kit it is its economical characteristics that makes specialists think about high compatibility of this product on the world market. The latest economical analysis shows that the No Foam Kit is currently available for ARFF vehicle models CF4000L (Amertek) and P-19 (Oshkosh). The estimated capital cost is only $
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ,500. The estimated pay back period is less than two weeks but in some circumstances this period may be prolonged to six months. But these are not the only benefits that No Foam Kit suggests to the owner because it necessary to underline that the owner won’t waste money on hazardous waste disposal, treatment of the wastewater stream and downtime of treatment plants due to upsets.

    Finally, it is evident that appropriate authority for making process changes should always be sought and obtained prior to procuring or implementing any of the technology mentioned here. As the principle values of our time are a human life and environmental protection so in such a way the ARFF vehicles will be developing. At the same time we can estimate that engine
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    rs and researchers will work on the security of flight because this problem is also very important especially if we take into account the fact that space journey is the question of the nearest future and accidents may happen even on space stations like it was on ‘Mir’ not a very long time ago.

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    Unfortunately there arise new problems that make the development of ARFF and airports’ security vitally important. I speak about the threat of terrorist attack that can be hardly predicted and that is why now practically all countries try to prevent any
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    isaster caused by different extremists. And, naturally, in such a situation all departments of fire fighters will face the danger first and to cope with it they will need the most up-to-date equipment, machines and technologies. I don’t have any doubts that ARFF vehicles do really correspond to such a demand of our time because now they have to use the most progressive technologies which may be used everywhere even in space. And one more factor in favor of ARFF vehicles and techniques is the fact that they are safe and environmentally friendly that is very important for the modern world. Thus, their history and role that they played, play and, certainly will play show that they have the right for existence, development, and protection of life


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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